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Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs

A chiral synthesis of a series of hexahydroisobenzofuran (HIBF) nucleosides has been accomplished via glycosylation of a stereo-defined (syn-isomer) sugar motif 16 with the appropriate silylated bases. All nucleoside analogs were obtained in 52–71% yield as a mixture of α- and β-anomeric products in...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Díaz-Rodríguez, Alba, Sanghvi, Yogesh S., Fernández, Susana, Schinazi, Raymond F., Theodorakis, Emmanuel A., Ferrero, Miguel, Gotor, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733237/
https://ncbi.nlm.nih.gov/pubmed/19300828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b818707j
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