CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β(2)AR in isogenic hPSC-derived cardiomyocytes

During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β(2)AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association studies, in vitro experiments with primary cells, and...

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發表在:Mol Ther Methods Clin Dev
Main Authors: Kondrashov, Alexander, Mohd Yusof, Nurul A.N., Hasan, Alveera, Goulding, Joëlle, Kodagoda, Thusharika, Hoang, Duc M., Vo, Nguyen T.N., Melarangi, Tony, Dolatshad, Nazanin, Gorelik, Julia, Hill, Stephen J., Harding, Sian E., Denning, Chris
格式: Artigo
語言:Inglês
出版: American Society of Gene & Cell Therapy 2020
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733025/
https://ncbi.nlm.nih.gov/pubmed/33335946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.10.019
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