CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β(2)AR in isogenic hPSC-derived cardiomyocytes

During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β(2)AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association studies, in vitro experiments with primary cells, and...

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Bibliografski detalji
Izdano u:Mol Ther Methods Clin Dev
Glavni autori: Kondrashov, Alexander, Mohd Yusof, Nurul A.N., Hasan, Alveera, Goulding, Joëlle, Kodagoda, Thusharika, Hoang, Duc M., Vo, Nguyen T.N., Melarangi, Tony, Dolatshad, Nazanin, Gorelik, Julia, Hill, Stephen J., Harding, Sian E., Denning, Chris
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2020
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733025/
https://ncbi.nlm.nih.gov/pubmed/33335946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.10.019
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