CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β(2)AR in isogenic hPSC-derived cardiomyocytes

During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β(2)AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association studies, in vitro experiments with primary cells, and...

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Bibliografske podrobnosti
izdano v:Mol Ther Methods Clin Dev
Main Authors: Kondrashov, Alexander, Mohd Yusof, Nurul A.N., Hasan, Alveera, Goulding, Joëlle, Kodagoda, Thusharika, Hoang, Duc M., Vo, Nguyen T.N., Melarangi, Tony, Dolatshad, Nazanin, Gorelik, Julia, Hill, Stephen J., Harding, Sian E., Denning, Chris
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2020
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733025/
https://ncbi.nlm.nih.gov/pubmed/33335946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.10.019
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