Targeted suicide gene therapy for liver cancer based on ribozyme-mediated RNA replacement through post-transcriptional regulation

Hepatocellular carcinoma (HCC) has high fatality rate and limited therapeutic options. Here, we propose a new anti-HCC approach with high cancer-selectivity and efficient anticancer effects, based on adenovirus-mediated Tetrahymena group I trans-splicing ribozymes specifically inducing targeted suic...

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Detalles Bibliográficos
Publicado en:Mol Ther Nucleic Acids
Main Authors: Han, Seung Ryul, Lee, Chang Ho, Im, Ji Young, Kim, Ju Hyun, Kim, Ji Hyun, Kim, Sung Jin, Cho, Young Woo, Kim, Eunkyung, Kim, Youngah, Ryu, Ji-Ho, Ju, Mi Ha, Jeong, Jin Sook, Lee, Seong-Wook
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732968/
https://ncbi.nlm.nih.gov/pubmed/33335800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.10.036
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