Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation

Hepatocellular carcinoma (HCC) has a high fatality rate and limited therapeutic options with side effects and low efficacy. Here, we proposed a new anti-HCC approach based on cancer-specific post-transcriptional targeting. To this end, trans-splicing ribozymes from Tetrahymena group I intron were de...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Kim, Juhyun, Won, Ranhui, Ban, Guyee, Ha Ju, Mi, Sook Cho, Kyung, Young Han, Sang, Jeong, Jin-Sook, Lee, Seong-Wook
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507181/
https://ncbi.nlm.nih.gov/pubmed/26189916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12315
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