Multiscale Simulations Examining Glycan Shield Effects on Drug Binding to Influenza Neuraminidase

Influenza neuraminidase is an important drug target. Glycans are present on neuraminidase and are generally considered to inhibit antibody binding via their glycan shield. In this work, we studied the effect of glycans on the binding kinetics of antiviral drugs to the influenza neuraminidase. We cre...

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Vydáno v:Biophys J
Hlavní autoři: Seitz, Christian, Casalino, Lorenzo, Konecny, Robert, Huber, Gary, Amaro, Rommie E., McCammon, J. Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732775/
https://ncbi.nlm.nih.gov/pubmed/33130120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.10.024
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