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Multiscale Simulations Examining Glycan Shield Effects on Drug Binding to Influenza Neuraminidase
Influenza neuraminidase is an important drug target. Glycans are present on neuraminidase and are generally considered to inhibit antibody binding via their glycan shield. In this work, we studied the effect of glycans on the binding kinetics of antiviral drugs to the influenza neuraminidase. We cre...
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| 出版年: | Biophys J |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7732775/ https://ncbi.nlm.nih.gov/pubmed/33130120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.10.024 |
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