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Microsecond Molecular Dynamics Simulations of Influenza Neuraminidase Suggest a Mechanism for the Increased Virulence of Stalk-Deletion Mutants

[Image: see text] Deletions in the stalk of the influenza neuraminidase (NA) surface protein are associated with increased virulence, but the mechanisms responsible for this enhanced virulence are unclear. Here we use microsecond molecular dynamics simulations to explore the effect of stalk deletion...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Durrant, Jacob D., Bush, Robin M., Amaro, Rommie E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002936/
https://ncbi.nlm.nih.gov/pubmed/27141956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b02655
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