Activation of LKB1 rescues 3T3-L1 adipocytes from senescence induced by Sirt1 knock-down: a pivotal role of LKB1 in cellular aging

Previous reports have shown that excess calorie intake promotes p53 dependent senescence in mouse adipose tissues. The objective of the current study was to address the mechanism underlying this observation, i.e. adipocyte aging. Using cultured 3T3-L1 cells, we investigated the involvement of energy...

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Foilsithe in:Aging (Albany NY)
Main Authors: Lan, Fan, Lin, Yan, Gao, Zhenfeng, Cacicedo, Jose M., Weikel, Karen, Ido, Yasuo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals 2020
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732306/
https://ncbi.nlm.nih.gov/pubmed/33040052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.104052
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