S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway

In this study, we used murine chondrocytes as an in vitro model and mice exhibiting destabilization of the medial meniscus (DMM) as an in vivo model to investigate the mechanisms through which S-allyl cysteine (SAC) alleviates osteoarthritis (OA). SAC significantly reduced apoptosis and senescence a...

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Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Shao, Zhenxuan, Pan, Zongyou, Lin, Jialiang, Zhao, Qingqian, Wang, Yuqian, Ni, Libin, Feng, Shiyi, Tian, Naifeng, Wu, Yaosen, Sun, Liaojun, Gao, Weiyang, Zhou, Yifei, Zhang, Xiaolei, Wang, Xiangyang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732291/
https://ncbi.nlm.nih.gov/pubmed/33027770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103757
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