An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

The pathophysiology of ineffective erythropoiesis in β-thalassemia is poorly understood. We report that RAP-011, an activin receptor IIA (ActRIIA) ligand trap, improved ineffective erythropoiesis, corrected anemia and limited iron overload in a mouse model of β-thalassemia intermedia. Expression of...

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Publicado no:Nat Med
Main Authors: Dussiot, Michael, Maciel, Thiago T, Fricot, Aurélie, Chartier, Céline, Negre, Olivier, Veiga, Joel, Grapton, Damien, Paubelle, Etienne, Payen, Emmanuel, Beuzard, Yves, Leboulch, Philippe, Ribeil, Jean-Antoine, Arlet, Jean-Benoit, Coté, Francine, Courtois, Geneviève, Ginzburg, Yelena Z, Daniel, Thomas O, Chopra, Rajesh, Sung, Victoria, Hermine, Olivier, Moura, Ivan C
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730561/
https://ncbi.nlm.nih.gov/pubmed/24658077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3468
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