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Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK

The nonreceptor tyrosine TEC kinases are key regulators of the immune system and play a crucial role in the pathogenesis of diverse hematological malignancies. In contrast to the substantial efforts in inhibitor development for Bruton’s tyrosine kinase (BTK), specific inhibitors of the other TEC kin...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Forster, Michael, Liang, Xiaojun Julia, Schröder, Martin, Gerstenecker, Stefan, Chaikuad, Apirat, Knapp, Stefan, Laufer, Stefan, Gehringer, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730235/
https://ncbi.nlm.nih.gov/pubmed/33291717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239269
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