Optimizing pharmacokinetics/pharmacodynamics of β-lactam/β-lactamase inhibitor combinations against high inocula of ESBL-producing bacteria

OBJECTIVES: Reduced in vitro β-lactam activity against a dense bacterial population is well recognized. It is commonly attributed to the presence of β-lactamase(s) and it is unknown whether the inoculum effect could be diminished by a β-lactamase inhibitor. We evaluated different β-lactam/β-lactamas...

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Bibliographische Detailangaben
Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Tam, Vincent H, Abodakpi, Henrietta, Wang, Weiqun, Ledesma, Kimberly R, Merlau, Paul R, Chan, Katrina, Altman, Rachel, Tran, Truc T, Nikolaou, Michael, Sofjan, Amelia K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729384/
https://ncbi.nlm.nih.gov/pubmed/33035321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa412
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