Optimizing pharmacokinetics/pharmacodynamics of β-lactam/β-lactamase inhibitor combinations against high inocula of ESBL-producing bacteria

OBJECTIVES: Reduced in vitro β-lactam activity against a dense bacterial population is well recognized. It is commonly attributed to the presence of β-lactamase(s) and it is unknown whether the inoculum effect could be diminished by a β-lactamase inhibitor. We evaluated different β-lactam/β-lactamas...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Tam, Vincent H, Abodakpi, Henrietta, Wang, Weiqun, Ledesma, Kimberly R, Merlau, Paul R, Chan, Katrina, Altman, Rachel, Tran, Truc T, Nikolaou, Michael, Sofjan, Amelia K
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729384/
https://ncbi.nlm.nih.gov/pubmed/33035321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa412
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