Combinatorial Pharmacodynamics of Ceftolozane-Tazobactam against Genotypically Defined β-Lactamase-Producing Escherichia coli: Insights into the Pharmacokinetics/Pharmacodynamics of β-Lactam–β-Lactamase Inhibitor Combinations

Despite a dearth of new agents currently being developed to combat multidrug-resistant Gram-negative pathogens, the combination of ceftolozane and tazobactam was recently approved by the Food and Drug Administration to treat complicated intra-abdominal and urinary tract infections. To characterize t...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Soon, Rachel L., Lenhard, Justin R., Bulman, Zackery P., Holden, Patricia N., Kelchlin, Pamela, Steenbergen, Judith N., Friedrich, Lawrence V., Forrest, Alan, Tsuji, Brian T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808171/
https://ncbi.nlm.nih.gov/pubmed/26729494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02635-15
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