Case Report: BAP1 Mutation and RAD21 Amplification as Predictive Biomarkers to PARP Inhibitor in Metastatic Intrahepatic Cholangiocarcinoma

INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) is a rare hepatobiliary cancer characterized by a poor prognosis and a limited response to conventional therapies. Currently chemotherapy is the only therapeutic option for patients with Stage IV ICC. Due to the poor response rate, there is an urge...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Sabbatino, Francesco, Liguori, Luigi, Malapelle, Umberto, Schiavi, Francesca, Tortora, Vincenzo, Conti, Valeria, Filippelli, Amelia, Tortora, Giampaolo, Ferrone, Cristina R., Pepe, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728995/
https://ncbi.nlm.nih.gov/pubmed/33330039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.567289
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