Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1, ARID1A and PBRM1), and mutation in one of these genes occurred in almost half of the carcinomas sequenced. We also identified freque...

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Detalhes bibliográficos
Main Authors: Jiao, Yuchen, Pawlik, Timothy M, Anders, Robert A, Selaru, Florin M, Streppel, Mirte M, Lucas, Donald J, Niknafs, Noushin, Guthrie, Violeta Beleva, Maitra, Anirban, Argani, Pedram, Offerhaus, G Johan A, Roa, Juan Carlos, Roberts, Lewis R, Gores, Gregory J, Popescu, Irinel, Alexandrescu, Sorin T, Dima, Simona, Fassan, Matteo, Simbolo, Michele, Mafficini, Andrea, Capelli, Paola, Lawlor, Rita T, Ruzzenente, Andrea, Guglielmi, Alfredo, Tortora, Giampaolo, de Braud, Filippo, Scarpa, Aldo, Jarnagin, William, Klimstra, David, Karchin, Rachel, Velculescu, Victor E, Hruban, Ralph H, Vogelstein, Bert, Kinzler, Kenneth W, Papadopoulos, Nickolas, Wood, Laura D
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013720/
https://ncbi.nlm.nih.gov/pubmed/24185509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2813
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