Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1, ARID1A and PBRM1), and mutation in one of these genes occurred in almost half of the carcinomas sequenced. We also identified freque...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Jiao, Yuchen, Pawlik, Timothy M, Anders, Robert A, Selaru, Florin M, Streppel, Mirte M, Lucas, Donald J, Niknafs, Noushin, Guthrie, Violeta Beleva, Maitra, Anirban, Argani, Pedram, Offerhaus, G Johan A, Roa, Juan Carlos, Roberts, Lewis R, Gores, Gregory J, Popescu, Irinel, Alexandrescu, Sorin T, Dima, Simona, Fassan, Matteo, Simbolo, Michele, Mafficini, Andrea, Capelli, Paola, Lawlor, Rita T, Ruzzenente, Andrea, Guglielmi, Alfredo, Tortora, Giampaolo, de Braud, Filippo, Scarpa, Aldo, Jarnagin, William, Klimstra, David, Karchin, Rachel, Velculescu, Victor E, Hruban, Ralph H, Vogelstein, Bert, Kinzler, Kenneth W, Papadopoulos, Nickolas, Wood, Laura D
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013720/
https://ncbi.nlm.nih.gov/pubmed/24185509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2813
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky