Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1, ARID1A and PBRM1), and mutation in one of these genes occurred in almost half of the carcinomas sequenced. We also identified freque...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Jiao, Yuchen, Pawlik, Timothy M, Anders, Robert A, Selaru, Florin M, Streppel, Mirte M, Lucas, Donald J, Niknafs, Noushin, Guthrie, Violeta Beleva, Maitra, Anirban, Argani, Pedram, Offerhaus, G Johan A, Roa, Juan Carlos, Roberts, Lewis R, Gores, Gregory J, Popescu, Irinel, Alexandrescu, Sorin T, Dima, Simona, Fassan, Matteo, Simbolo, Michele, Mafficini, Andrea, Capelli, Paola, Lawlor, Rita T, Ruzzenente, Andrea, Guglielmi, Alfredo, Tortora, Giampaolo, de Braud, Filippo, Scarpa, Aldo, Jarnagin, William, Klimstra, David, Karchin, Rachel, Velculescu, Victor E, Hruban, Ralph H, Vogelstein, Bert, Kinzler, Kenneth W, Papadopoulos, Nickolas, Wood, Laura D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013720/
https://ncbi.nlm.nih.gov/pubmed/24185509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2813
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge