Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model

Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD. It has been reported that beta-hydroxybutyrate (BHB), one of the main ketone bodies produ...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Yamanashi, Takehiko, Iwata, Masaaki, Shibushita, Midori, Tsunetomi, Kyohei, Nagata, Mayu, Kajitani, Naofumi, Miura, Akihiko, Matsuo, Ryoichi, Nishiguchi, Tsuyoshi, Kato, Takahiro A., Setoyama, Daiki, Shirayama, Yukihiko, Watanabe, Ken, Shinozaki, Gen, Kaneko, Koichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728809/
https://ncbi.nlm.nih.gov/pubmed/33303808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78410-2
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