Prefrontal cortex infusion of beta‐hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant‐like effects in a rodent model of depression

AIMS: Neuroinflammation is deeply related to the pathophysiology of depression. Beta‐hydroxybutyrate (BHB), which is an endogenous ketone body, exerts anti‐inflammatory effects, and peripheral administration of BHB induces antidepressant effects in an animal model of depression; however, it is uncle...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuropsychopharmacol Rep
Prif Awduron: Kajitani, Naofumi, Iwata, Masaaki, Miura, Akihiko, Tsunetomi, Kyohei, Yamanashi, Takehiko, Matsuo, Ryoichi, Nishiguchi, Tsuyoshi, Fukuda, Saki, Nagata, Mayu, Shibushita, Midori, Yamauchi, Takahira, Pu, Shenghong, Shirayama, Yukihiko, Watanabe, Ken, Kaneko, Koichi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722664/
https://ncbi.nlm.nih.gov/pubmed/32125791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/npr2.12099
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