β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares

Aging and lipotoxicity are two major risk factors for gout that are linked by the activation of NLRP3 inflammasome. Neutrophil-mediated production of IL-1β drives gouty flares that cause joint destruction, intense pain, and fever. However, metabolites that impact neutrophil inflammasome remain unkno...

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Publicado no:Cell Rep
Main Authors: Goldberg, Emily L., Asher, Jennifer L., Molony, Ryan D., Shaw, Albert C., Zeiss, Caroline J., Wang, Chao, Morozova-Roche, Ludmilla A., Herzog, Raimund I., Iwasaki, Akiko, Dixit, Vishwa Deep
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527297/
https://ncbi.nlm.nih.gov/pubmed/28249154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.004
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