CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection

cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are immune sensors that synthesize nucleotide second messengers and initiate antiviral responses in bacterial and animal cells. Here, we discover Enterobacter cloacae CD-NTase-associated protein 4 (Cap4) as a founding member of a diverse famil...

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Foilsithe in:Cell
Main Authors: Lowey, Brianna, Whiteley, Aaron T., Keszei, Alexander F.A., Morehouse, Benjamin R., Mathews, Ian T., Antine, Sadie P., Cabrera, Victor J., Kashin, Dmitry, Niemann, Percy, Jain, Mohit, Schwede, Frank, Mekalanos, John J., Shao, Sichen, Lee, Amy S.Y., Kranzusch, Philip J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728545/
https://ncbi.nlm.nih.gov/pubmed/32544385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.05.019
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