Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity

Bacteria possess an array of defenses against foreign invaders, including a broadly-distributed bacteriophage defense system termed CBASS (Cyclic oligonucleotide-Based Anti-phage Signaling System). In CBASS systems, a cGAS/DncV-like nucleotidyltransferase synthesizes cyclic di- or trinucleotide seco...

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Publicado no:Mol Cell
Main Authors: Lau, Rebecca K., Ye, Qiaozhen, Birkholz, Erica A., Berg, Kyle R., Patel, Lucas, Mathews, Ian T., Watrous, Jeramie D., Ego, Kaori, Whiteley, Aaron T., Lowey, Brianna, Mekalanos, John J., Kranzusch, Philip J., Jain, Mohit, Pogliano, Joe, Corbett, Kevin D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065454/
https://ncbi.nlm.nih.gov/pubmed/31932164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.12.010
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