High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

During mammalian gastrulation, germ layers arise and are shaped into the body plan while extraembryonic layers sustain the embryo. Human embryonic stem cells, cultured with BMP4 on extracellular matrix micro-discs, reproducibly differentiate into gastruloids, expressing markers of germ layers and ex...

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Опубликовано в: :eLife
Главные авторы: Minn, Kyaw Thu, Fu, Yuheng C, He, Shenghua, Dietmann, Sabine, George, Steven C, Anastasio, Mark A, Morris, Samantha A, Solnica-Krezel, Lilianna
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2020
Предметы:
Developmental Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728446/
https://ncbi.nlm.nih.gov/pubmed/33206048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59445
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