High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

During mammalian gastrulation, germ layers arise and are shaped into the body plan while extraembryonic layers sustain the embryo. Human embryonic stem cells, cultured with BMP4 on extracellular matrix micro-discs, reproducibly differentiate into gastruloids, expressing markers of germ layers and ex...

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Veröffentlicht in:eLife
Hauptverfasser: Minn, Kyaw Thu, Fu, Yuheng C, He, Shenghua, Dietmann, Sabine, George, Steven C, Anastasio, Mark A, Morris, Samantha A, Solnica-Krezel, Lilianna
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2020
Schlagworte:
Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728446/
https://ncbi.nlm.nih.gov/pubmed/33206048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59445
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