Rapamycin Eyedrops Increased CD4(+)Foxp3(+) Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface

Dry eye disease (DED), one of the most prevalent conditions among the elderly, is a chronic inflammatory disorder that disrupts tear film stability and causes ocular surface damage. Aged C57BL/6J mice spontaneously develop DED. Rapamycin is a potent immunosuppressant that prolongs the lifespan of se...

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Pubblicato in:Int J Mol Sci
Autori principali: Trujillo-Vargas, Claudia M., Kutlehria, Shallu, Hernandez, Humberto, de Souza, Rodrigo G., Lee, Andrea, Yu, Zhiyuan, Pflugfelder, Stephen C., Singh, Mandip, de Paiva, Cintia S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7727717/
https://ncbi.nlm.nih.gov/pubmed/33255287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21238890
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