Goblet cell loss abrogates ocular surface immune tolerance

Intestinal epithelial cells condition tolerogenic properties in DCs. Aqueous-deficient dry eye is associated with goblet cell (GC) loss and increased IFN-γ expression in the conjunctiva. We hypothesized that loss of GCs reduces tolerance-inducing properties of antigen presenting cells (APCs) in the...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: Ko, Byung Yi, Xiao, Yangyan, Barbosa, Flavia L., de Paiva, Cintia S., Pflugfelder, Stephen C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821180/
https://ncbi.nlm.nih.gov/pubmed/29415888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98222
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