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Goblet cell loss abrogates ocular surface immune tolerance
Intestinal epithelial cells condition tolerogenic properties in DCs. Aqueous-deficient dry eye is associated with goblet cell (GC) loss and increased IFN-γ expression in the conjunctiva. We hypothesized that loss of GCs reduces tolerance-inducing properties of antigen presenting cells (APCs) in the...
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| Veröffentlicht in: | JCI Insight |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5821180/ https://ncbi.nlm.nih.gov/pubmed/29415888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98222 |
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