Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye

Objective: The purpose of this study was to evaluate the potential of voclosporin (VOS) in preventing goblet cell (GC) loss and modulating interferon-gamma (IFN-γ) producing CD4(+) T cells in the mouse desiccating stress (DS) dry eye model. Methods: Mice were subjected to DS and treated topically wi...

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Detalhes bibliográficos
Publicado no:J Ocul Pharmacol Ther
Main Authors: Alam, Jehan, de Souza, Rodrigo G., Yu, Zhiyuan, Stern, Michael E., de Paiva, Cintia S., Pflugfelder, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703159/
https://ncbi.nlm.nih.gov/pubmed/32721249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2020.0005
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