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Bullet points to evaluate the performance of the middle-down proteomics workflow for histone modification analysis

Middle-down proteomics has emerged as the method of choice to study combinatorial histone post translational modifications (PTMs). In the common bottom-up workflow, histones are digested into relatively short peptides (4–20 aa), separated using reversed-phase chromatography and analyzed using typica...

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Detalhes bibliográficos
Publicado no:Methods
Main Authors: Coradin, Mariel, Mendoza, Mariel R., Sidoli, Simone, Alpert, Andrew J., Lu, Congcong, Garcia, Benjamin A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7727281/
https://ncbi.nlm.nih.gov/pubmed/32070774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2020.01.013
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