Thermostability profiling of MHC-bound peptides: a new dimension in immunopeptidomics and aid for immunotherapy design

The features of peptide antigens that contribute to their immunogenicity are not well understood. Although the stability of peptide-MHC (pMHC) is known to be important, current assays assess this interaction only for peptides in isolation and not in the context of natural antigen processing and pres...

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Publicado no:Nat Commun
Main Authors: Jappe, Emma C., Garde, Christian, Ramarathinam, Sri H., Passantino, Ethan, Illing, Patricia T., Mifsud, Nicole A., Trolle, Thomas, Kringelum, Jens V., Croft, Nathan P., Purcell, Anthony W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726561/
https://ncbi.nlm.nih.gov/pubmed/33298915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20166-4
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