Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors

Primary effusion lymphoma (PEL) has a very poor prognosis. To evaluate the contributions of enhancers/promoters interactions to PEL cell growth and survival, here we produce H3K27ac HiChIP datasets in PEL cells. This allows us to generate the PEL enhancer connectome, which links enhancers and promot...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Wang, Chong, Zhang, Luyao, Ke, Liangru, Ding, Weiyue, Jiang, Sizun, Li, Difei, Narita, Yohei, Hou, Isabella, Liang, Jun, Li, Shijun, Xiao, Haipeng, Gottwein, Eva, Kaye, Kenneth M., Teng, Mingxiang, Zhao, Bo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726151/
https://ncbi.nlm.nih.gov/pubmed/33298918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20136-w
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