Kaposi’s Sarcoma-Associated Herpesvirus Drives a Super-Enhancer-Mediated Survival Gene Expression Program in Primary Effusion Lymphoma

Kaposi’s sarcoma-associated herpesvirus (KSHV) causes primary effusion lymphoma (PEL). The cellular transcription factor (TF) interferon (IFN) regulatory factor 4 (IRF4) is an essential oncogene in PEL, but its specific role in PEL and how KSHV deregulates IRF4 remain unknown. Here, we report that t...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Manzano, Mark, Günther, Thomas, Ju, Hyunwoo, Nicholas, John, Bartom, Elizabeth T., Grundhoff, Adam, Gottwein, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448273/
https://ncbi.nlm.nih.gov/pubmed/32843547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01457-20
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