PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC

High expression of programmed death-ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) cells usually inhibits the proliferation and functions of T cells, leading to immune suppression in tumor microenvironment. However, very little has been described regarding the mechanism of PD-L1 overexpression i...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Wang, Xiao, Liang, Chao, Yao, Xin, Yang, Ruo-Han, Zhang, Zhan-Sheng, Liu, Fan-Ye, Li, Wen-Qi, Pei, Shu-Hua, Ma, Jing, Xie, Song-Qiang, Fang, Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725877/
https://ncbi.nlm.nih.gov/pubmed/33324209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.577108
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