Structural and biochemical analyses of an aminoglycoside 2′-N-acetyltransferase from Mycolicibacterium smegmatis

The expression of aminoglycoside-modifying enzymes represents a survival strategy of antibiotic-resistant bacteria. Aminoglycoside 2′-N-acetyltransferase [AAC(2′)] neutralizes aminoglycoside drugs by acetylation of their 2′ amino groups in an acetyl coenzyme A (CoA)-dependent manner. To understand t...

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Vydáno v:Sci Rep
Hlavní autoři: Jeong, Chang-Sook, Hwang, Jisub, Do, Hackwon, Cha, Sun-Shin, Oh, Tae-Jin, Kim, Hak Jun, Park, Hyun Ho, Lee, Jun Hyuck
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725843/
https://ncbi.nlm.nih.gov/pubmed/33299080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78699-z
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