Structural and biochemical analyses of an aminoglycoside 2′-N-acetyltransferase from Mycolicibacterium smegmatis

The expression of aminoglycoside-modifying enzymes represents a survival strategy of antibiotic-resistant bacteria. Aminoglycoside 2′-N-acetyltransferase [AAC(2′)] neutralizes aminoglycoside drugs by acetylation of their 2′ amino groups in an acetyl coenzyme A (CoA)-dependent manner. To understand t...

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Bibliographic Details
Published in:	Sci Rep
Main Authors:	Jeong, Chang-Sook, Hwang, Jisub, Do, Hackwon, Cha, Sun-Shin, Oh, Tae-Jin, Kim, Hak Jun, Park, Hyun Ho, Lee, Jun Hyuck
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group UK 2020
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7725843/ https://ncbi.nlm.nih.gov/pubmed/33299080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78699-z
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Structural and biochemical analyses of an aminoglycoside 2′-N-acetyltransferase from Mycolicibacterium smegmatis

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