Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models

Metabolic syndrome, a condition involving obesity and hypertension, increases the risk of aging-associated diseases such as age-related macular degeneration (AMD). Here, we demonstrated that high-fat diet (HFD)-fed mice accumulated oxidized low-density lipoprotein (ox-LDL) in macrophages through the...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Nagai, Norihiro, Kawashima, Hirohiko, Toda, Eriko, Homma, Kohei, Osada, Hideto, Guzman, Naymel A., Shibata, Shinsuke, Uchiyama, Yasuo, Okano, Hideyuki, Tsubota, Kazuo, Ozawa, Yoko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725839/
https://ncbi.nlm.nih.gov/pubmed/33299105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01483-2
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