Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering

Statins induce plaque regression characterized by reduced macrophage content in humans, but the underlying mechanisms remain speculative. Studying the translational APOE*3-Leiden.CETP mouse model with a humanized lipoprotein metabolism, we find that systemic cholesterol lowering by oral atorvastatin...

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Detalhes bibliográficos
Publicado no:Basic Res Cardiol
Main Authors: Härdtner, Carmen, Kornemann, Jan, Krebs, Katja, Ehlert, Carolin A., Jander, Alina, Zou, Jiadai, Starz, Christopher, Rauterberg, Simon, Sharipova, Diana, Dufner, Bianca, Hoppe, Natalie, Dederichs, Tsai-Sang, Willecke, Florian, Stachon, Peter, Heidt, Timo, Wolf, Dennis, von zur Mühlen, Constantin, Madl, Josef, Kohl, Peter, Kaeser, Rafael, Boettler, Tobias, Pieterman, Elsbeth J., Princen, Hans M. G., Ho-Tin-Noé, Benoît, Swirski, Filip K., Robbins, Clinton S., Bode, Christoph, Zirlik, Andreas, Hilgendorf, Ingo
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725697/
https://ncbi.nlm.nih.gov/pubmed/33296022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-00838-4
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