Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe(–/–) mice

OBJECTIVE: Interferon regulatory factor (IRF) 5 is a transcription factor known for promoting M1 type macrophage polarization in vitro. Given the central role of inflammatory macrophages in promoting atherosclerotic plaque progression, we hypothesize that myeloid cell-specific deletion of IRF5 is pr...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Mol Metab
Asıl Yazarlar: Leipner, Julia, Dederichs, Tsai-Sang, von Ehr, Alexander, Rauterberg, Simon, Ehlert, Carolin, Merz, Julian, Dufner, Bianca, Hoppe, Natalie, Krebs, Katja, Heidt, Timo, von zur Muehlen, Constantin, Stachon, Peter, Ley, Klaus, Wolf, Dennis, Zirlik, Andreas, Bode, Christoph, Hilgendorf, Ingo, Härdtner, Carmen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2021
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178123/
https://ncbi.nlm.nih.gov/pubmed/33991749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101250
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