Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe(–/–) mice

OBJECTIVE: Interferon regulatory factor (IRF) 5 is a transcription factor known for promoting M1 type macrophage polarization in vitro. Given the central role of inflammatory macrophages in promoting atherosclerotic plaque progression, we hypothesize that myeloid cell-specific deletion of IRF5 is pr...

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Dades bibliogràfiques
Publicat a:Mol Metab
Autors principals: Leipner, Julia, Dederichs, Tsai-Sang, von Ehr, Alexander, Rauterberg, Simon, Ehlert, Carolin, Merz, Julian, Dufner, Bianca, Hoppe, Natalie, Krebs, Katja, Heidt, Timo, von zur Muehlen, Constantin, Stachon, Peter, Ley, Klaus, Wolf, Dennis, Zirlik, Andreas, Bode, Christoph, Hilgendorf, Ingo, Härdtner, Carmen
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178123/
https://ncbi.nlm.nih.gov/pubmed/33991749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101250
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