Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe(–/–) mice

OBJECTIVE: Interferon regulatory factor (IRF) 5 is a transcription factor known for promoting M1 type macrophage polarization in vitro. Given the central role of inflammatory macrophages in promoting atherosclerotic plaque progression, we hypothesize that myeloid cell-specific deletion of IRF5 is pr...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Leipner, Julia, Dederichs, Tsai-Sang, von Ehr, Alexander, Rauterberg, Simon, Ehlert, Carolin, Merz, Julian, Dufner, Bianca, Hoppe, Natalie, Krebs, Katja, Heidt, Timo, von zur Muehlen, Constantin, Stachon, Peter, Ley, Klaus, Wolf, Dennis, Zirlik, Andreas, Bode, Christoph, Hilgendorf, Ingo, Härdtner, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178123/
https://ncbi.nlm.nih.gov/pubmed/33991749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101250
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