Population variability in the generation and selection of T-cell repertoires

The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selection based on the recognition of random self-peptides presented on the major histocompatibility complex. These processes le...

Full description

Saved in:
Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Sethna, Zachary, Isacchini, Giulio, Dupic, Thomas, Mora, Thierry, Walczak, Aleksandra M., Elhanati, Yuval
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725366/
https://ncbi.nlm.nih.gov/pubmed/33296360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008394
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items