Berberine Represses β-Catenin Translation Involving 4E-BPs in Hepatocellular Carcinoma Cells

Aberrant activation of Wnt/β-catenin axis occurs in several gastrointestinal malignancies due to inactivating mutations of adenomatous polyposis coli (in colorectal cancer) or activating mutations of β-catenin itself [in hepatocellular carcinoma (HCC)]. These lead to β-catenin stabilization, increas...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Vishnoi, Kanchan, Ke, Rong, Saini, Karan S., Viswakarma, Navin, Nair, Rakesh Sathish, Das, Subhasis, Chen, Zhengjia, Rana, Ajay, Rana, Basabi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2021
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725064/
https://ncbi.nlm.nih.gov/pubmed/33130557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000029
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