CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia

GABAergic dysfunctions have been implicated in the pathogenesis of schizophrenia, especially the associated cognitive impairments. The GABA synthetic enzyme glutamate decarboxylase 67-kDa isoform (GAD67) encoded by the GAD1 gene is downregulated in the brains of patients with schizophrenia. Furtherm...

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Publicado no:Transl Psychiatry
Main Authors: Fujihara, Kazuyuki, Yamada, Kazuo, Ichitani, Yukio, Kakizaki, Toshikazu, Jiang, Weiru, Miyata, Shigeo, Suto, Takashi, Kato, Daiki, Saito, Shigeru, Watanabe, Masahiko, Kajita, Yuki, Ohshiro, Tomokazu, Mushiake, Hajime, Miyasaka, Yoshiki, Mashimo, Tomoji, Yasuda, Hiroki, Yanagawa, Yuchio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723991/
https://ncbi.nlm.nih.gov/pubmed/33293518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-020-01108-6
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