Loss of Glutamate Decarboxylase 67 in Somatostatin-Expressing Neurons Leads to Anxiety-Like Behavior and Alteration in the Akt/GSK3β Signaling Pathway

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder worldwide. Several lines of evidence suggest that the dysfunction of somatostatin (SOM) neurons is associated with the pathophysiology of MDD. Importantly, most SOM neurons are γ-aminobutyric acid (GABA) interneurons. However...

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Vydáno v:Front Behav Neurosci
Hlavní autoři: Miyata, Shigeo, Kumagaya, Ryota, Kakizaki, Toshikazu, Fujihara, Kazuyuki, Wakamatsu, Kaori, Yanagawa, Yuchio
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591520/
https://ncbi.nlm.nih.gov/pubmed/31275123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2019.00131
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