Icariin Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension via the Inhibition of TGF-β1/Smads Pathway in Rats

BACKGROUND: Pulmonary artery remodeling is important in the development of pulmonary artery hypertension. The TGF-β1/Smads signaling pathway is activated in pulmonary arterial hypertension (PAH) in rats. Icariin (ICA) suppresses the TGF-β1/Smad2 pathway in myocardial fibrosis in rats. Therefore, we...

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Pubblicato in:Evid Based Complement Alternat Med
Autori principali: Xiang, Yijia, Cai, Changhong, Wu, Yonghui, Yang, Lebing, Ye, Shiyong, Zhao, Huan, Zeng, Chunlai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723481/
https://ncbi.nlm.nih.gov/pubmed/33335559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/9238428
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