A single-cell landscape of high-grade serous ovarian cancer

Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor prognosis(1). To comprehensively characterize the HGSOC ascites ecosystem, we used single-cell RNA-seq (scRNA-seq) to profile ~11,...

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Publié dans:Nat Med
Auteurs principaux: Izar, Benjamin, Tirosh, Itay, Stover, Elizabeth H, Wakiro, Isaac, Cuoco, Michael S, Alter, Idan, Rodman, Christopher, Leeson, Rachel, Su, Mei-Ju, Shah, Parin, Iwanicki, Marcin, Walker, Sarah R, Kanodia, Abhay, Melms, Johannes C, Mei, Shaolin, Lin, Jia-Ren, Porter, Caroline B M, Slyper, Michal, Waldman, Julia, Jerby-Arnon, Livnat, Ashenberg, Orr, Brinker, Titus J, Mills, Caitlin, Rogava, Meri, Vigneau, Sébastien, Sorger, Peter K, Garraway, Levi A, Konstantinopoulos, Panagiotis A, Liu, Joyce F, Matulonis, Ursula, Johnson, Bruce E, Rozenblatt-Rosen, Orit, Rotem, Asaf, Regev, Aviv
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723336/
https://ncbi.nlm.nih.gov/pubmed/32572264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0926-0
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