A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Immune checkpoint inhibitors (ICIs) produce durable responses in some melanoma patients, but many patients derive no clinical benefit, and the molecular underpinnings of such resistance remain elusive. Here, we leveraged single-cell RNA sequencing (scRNA-seq) from 33 melanoma tumors and computationa...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Jerby-Arnon, Livnat, Shah, Parin, Cuoco, Michael S., Rodman, Christopher, Su, Mei-Ju, Melms, Johannes C., Leeson, Rachel, Kanodia, Abhay, Mei, Shaolin, Lin, Jia-Ren, Wang, Shu, Rabasha, Bokang, Liu, David, Zhang, Gao, Margolais, Claire, Ashenberg, Orr, Ott, Patrick A., Buchbinder, Elizabeth I., Haq, Rizwan, Hodi, F. Stephen, Boland, Genevieve M., Sullivan, Ryan J., Frederick, Dennie T., Miao, Benchun, Moll, Tabea, Flaherty, Keith T., Herlyn, Meenhard, Jenkins, Russell W., Thummalapalli, Rohit, Kowalczyk, Monika S., Cañadas, Israel, Schilling, Bastian, Cartwright, Adam N.R., Luoma, Adrienne M., Malu, Shruti, Hwu, Patrick, Bernatchez, Chantale, Forget, Marie-Andrée, Barbie, David A., Shalek, Alex K., Tirosh, Itay, Sorger, Peter K., Wucherpfennig, Kai, Van Allen, Eliezer M., Schadendorf, Dirk, Johnson, Bruce E., Rotem, Asaf, Rozenblatt-Rosen, Orit, Garraway, Levi A., Yoon, Charles H., Izar, Benjamin, Regev, Aviv
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410377/
https://ncbi.nlm.nih.gov/pubmed/30388455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.09.006
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