Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription

INTRODUCTION: Despite the long-observed correlation between H3K9me3, chromatin architecture, and transcriptional repression, how H3K9me3 regulates genome higher-order organization and transcriptional activity in living cells remains unclear. RESULT: Here, we develop EpiGo (Epigenetic perturbation in...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Feng, Ying, Wang, Yao, Wang, Xiangnan, He, Xiaohui, Yang, Chen, Naseri, Ardalan, Pederson, Thoru, Zheng, Jing, Zhang, Shaojie, Xiao, Xiao, Xie, Wei, Ma, Hanhui
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722448/
https://ncbi.nlm.nih.gov/pubmed/33292531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02201-1
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