Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway

Vertebrate Hedgehog signals are transduced through the primary cilium, a specialized lipid microdomain that is required for Smoothened activation. Cilia-associated sterol and oxysterol lipids bind to Smoothened to activate the Hedgehog pathway, but how ciliary lipids are regulated is incompletely un...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Findakly, Sarah, Daggubati, Vikas, Garcia, Galo, LaStella, Sydney A., Choudhury, Abrar, Tran, Cecilia, Li, Amy, Tong, Pakteema, Garcia, Jason Q., Puri, Natasha, Reiter, Jeremy F., Xu, Libin, Raleigh, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721912/
https://ncbi.nlm.nih.gov/pubmed/33284321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202002026
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