EMBR-16. SMOOTHENED-ACTIVATING LIPIDS DRIVE RESISTANCE TO CDK4/6 INHIBITION IN HEDGEHOG-ASSOCIATED MEDULLOBLASTOMA

BACKGROUND: Medulloblastoma is an aggressive pediatric brain tumor that is associated with misactivation of the Hedgehog (HH) pathway. Our lab has shown that CDK6, a critical activator of the cell cycle, is a direct transcriptional target of oncogenic HH signaling, and that inhibiting CDK6 blocks th...

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Vydáno v:Neuro Oncol
Hlavní autoři: Daggubati, Vikas, Hochstelter, Jordan, Bommireddy, Anirudh, Choudhury, Abrar, Krup, Alexis Leigh, Choski, Pervinder, Tong, Pakteema, Li, Amy, Xu, Libin, Reiter, Jeremy, Raleigh, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Embryonal Tumors
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168232/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.034
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