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Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are a growing family of bioactive natural products. They are challenging to prepare by chemical routes due to the polycyclic and densely functionalized backbone. Through functional characterization and investigation, we herein...

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Publicat a:Nat Commun
Autors principals: Sun, Chenghai, Luo, Zhenyao, Zhang, Wenlu, Tian, Wenya, Peng, Haidong, Lin, Zhi, Deng, Zixin, Kobe, Bostjan, Jia, Xinying, Qu, Xudong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721796/
https://ncbi.nlm.nih.gov/pubmed/33288748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20022-5
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