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Biosynthesis of plant tetrahydroisoquinoline alkaloids through an imine reductase route
Herein, we report a biocatalytic approach to synthesize plant tetrahydroisoquinoline alkaloids (THIQAs) from dihydroisoquinoline (DHIQ) precursors using imine reductases and N-methyltransferase (NMT). The imine reductase IR45 was engineered to significantly expand its substrate specificity, enabling...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7067268/ https://ncbi.nlm.nih.gov/pubmed/32190259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc03773j |
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