Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials

We report herein the syntheses of 79 derivatives of the 4(3H)-quinazolinones and their structure–activity relationship (SAR) against methicillin-resistant Staphylococcus aureus (MRSA). Twenty one analogs were further evaluated in in vitro assays. Subsequent investigation of the pharmacokinetic prope...

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Pubblicato in:J Med Chem
Autori principali: Qian, Yuanyuan, Allegretta, Giuseppe, Janardhanan, Jeshina, Peng, Zhihong, Mahasenan, Kiran V., Lastochkin, Elena, Gozun, Melissa Malia N., Tejera, Sara, Schroeder, Valerie A., Wolter, William R., Feltzer, Rhona, Mobashery, Shahriar, Chang, Mayland
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720656/
https://ncbi.nlm.nih.gov/pubmed/32343145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00153
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