Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia

Hereditary spastic paraplegias (HSPs) are caused by a length-dependent axonopathy of long corticospinal neurons, but how axons of these cortical projection neurons (PNs) degenerate remains elusive. We generated isogenic human pluripotent stem cell (hPSC) lines for two ATL1 missense mutations associa...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Acta Neuropathol Commun
Egile Nagusiak: Mou, Yongchao, Dong, Yi, Chen, Zhenyu, Denton, Kyle R., Duff, Michael O., Blackstone, Craig, Zhang, Su-Chun, Li, Xue-Jun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2020
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720406/
https://ncbi.nlm.nih.gov/pubmed/33287888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01088-0
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